News

Welcome to the QUBE Lab at SKKU, S. Korea!

We are experimental and theoretical biophysicists working on understanding the influence of quantum spin effects on biological function and their medical applications.

Our strong background in spin chemistry allows us to tackle key questions in quantum biophysics. We are particularly interested in the radical pair mechanism and its role in biological systems.

We approach these scientific questions by developing experimental techniques and software, and expertise to provide a comprehensive understanding of the quantum effects in biological systems.

We are seeking highly motivated undergraduate students, graduate students, and postdoctoral research fellows. If you would like to know more about our group and research, please send a self-introduction and CV to Prof. Lewis M. Antill at lewis.antill@g.skku.edu

Research

Our group focusses on understanding the influence of quantum effects on biological function and their medical applications.

Our Approach

We approach these scientific questions by combining a range of techniques and expertise to provide a comprehensive understanding of the quantum effects in biological systems.

Technique Development

Providing the right tools for the job.

Software and Theory Development

Providing the correct interpretation of experimental findings.

Collaboration

Working with experts in key areas relevant to the project.

Publications

Click here for Google Scholar

  • Recent Publications

    • Single-photon quantum spin effects in biomolecules

      Published in Nature Photonics!
      The effects of magnetic fields on quantum entangled biomolecules are detected using a highly sensitive magneto-fluorescence fluctuation microspectroscopy technique. This marks an important advance in experimental quantum life sciences at the single-photon level.

    • Open-source spin dynamics software - RadicalPy

      Published in the Journal of Chemical Theory and Computation!
      We hope that this versatile framework provides the means for students and researchers to perform correct and complex radical pair dynamics simulations with relative ease, making it ideal as a teaching or learning tool for creating quick simulations on the fly.


    • Engineered magnetosensitive fluorescent proteins

      We recently created a new class of magnetosensitive fluorescent proteins (MFPs), which we now show overcome these challenges and represent the first biological quantum-based sensor that functions at physiological conditions and in living cells.


  • Publication List

    # First author, * Corresponding author

  • [10] J. Gravell#, P. D. F. Murton#, T. L. Pitcher, K. B. Henbest, J. Schmidt, M. M. Buffett, G. Moise, A. S. Gehrckens, D. R. Cubbin, A. Štuhec, L. M. Antill, O. Paré-Labrosse, M. Bassetto, G. Saberamoli, J. Xu, C. Langebrake, M. Liedvogel, E. Schleicher, S. Weber, R. Bartölke*, H. Mouritsen*, P. J. Hore*, S. R. Mackenzie*, C. R. Timmel*, Spectroscopic characterisation of radical pair photochemistry in non-migratory avian cryptochromes: magnetic field effects in GgCry4a, J. Am. Chem. Soc., 147, 28, 24286-24298, 2025 (IF 14.5; JCR 8.6%)


    [9] L. M. Antill#*, M. Kohmura, C. Jimbo, and K. Maeda, Introduction of magneto-fluorescence fluctuation microspectroscopy for investigating quantum effects in biology, Nat. Photonics, 19, 178–186, 2025 (IF 32.3; JCR 1.0%)

    Press Releases
    Nature Photonics News & Views
    Oxford Instruments Andor - Application Note
    Azo Optics

    [8] G. Abrahams#*, V. Spreng, A. Štuhec, I. Kempf, J. James, K. Sechkar, S. Stacey, V. Trelles-Fernandez, L. M. Antill, M. Ingaramo, A. York, J. P. Tetienne, C. R. Timmel, and H. Steel*, Quantum Spin Resonance in Engineered Magneto-Sensitive Fluorescent Proteins Enables Multi-Modal Sensing in Living Cells, bioRxiv, 2024, Under Review


    [7] L. M. Antill#* and E. Vatai#*, RadicalPy: a tool for spin dynamics simulations, J. Chem. Theory Comput. 21, 20, 9488–9499, 2024 (IF 5.7; JCR 11.4%)

    Related Links
    Github Repo
    Documentation

    [6] M. Hanić#, L. M. Antill#, A. S. Gehrckens#, J. Schmidt, K. Görtemaker, R. Bartölke, T. J. El-Baba, J. Xu, K. W. Koch, H. Mouritsen, J. L. P. Benesch, P. J. Hore, and I. A. Solov’yov*, Dimerization of European robin cryptochrome 4a, J. Phys. Chem. B 127, 28, 6251–6264, 2023 (IF 2.8)


    [5] L. M. Antill#, S. Takizawa, S. Murata, and J. R. Woodward*, Photoinduced flavin-tryptophan electron transfer across vesicle membranes generates magnetic field sensitive radical pairs, Mol. Phys. 117, 2594–2603, 2018 (IF 1.6)


    [4] L. M. Antill# and J. R. Woodward*, Flavin Adenine Dinucleotide Photochemistry Is Magnetic Field Sensitive at Physiological pH, J. Phys. Chem. Lett. 9, 2691– 2696, 2018 (IF 4.9)


    [3] L. M. Antill#, J. P. Beardmore#, and J. R. Woodward*, Time-resolved optical absorption microspectroscopy of magnetic field sensitive flavin photochemistry, Rev. Sci. Instrum. 89, 023707, 2018 (IF 1.3)


    [2] J. P. Beardmore#, L. M. Antill#, and J. R. Woodward*, Optical Absorption and Magnetic Field Effect Based Imaging of Transient Radicals, Angew. Chem. Int. Ed. 54, 8494–8497, 2015 (IF 16.1; JCR 6.9%)

    Press Releases
    The University of Tokyo
    The University of Tokyo (日本語)
    Science Daily
    Nanowerk
    Phys.org
    EurekAlert!

    [1] L. M. Antill#, M. M. Neidhardt, J. Kirres, S. Beardsworth, M. Mansueto, A. Baro, and S. Laschat*, Ionic liquid crystals derived from guanidinium salts: induction of columnar mesophases by bending of the cationic core, Liq. Cryst. 41, 976–985, 2014 (IF 2.4)

    PI: Lewis M. Antill

    ...

    Lewis is a son and a grandson of a mechanical engineer and a master carpenter, respectively, which led to him tinkering in the family workshops from the age of four. The skills developed through the course of his childhood have proven invaluable during his academic career as a spin chemist who specialises in developing experimental techniques for understanding quantum spin effects in biological systems. He is a pioneer of magnetic field effect-based microspectroscopy, in which seminal papers were published during his PhD. His PhD thesis at The University of Tokyo (2014-2018) focused on developing transient optical absorption-based microspectroscopy for investigating flavin-based spin-correlated radical pairs (see Angew. Chem. Int. Ed. and Rev. Sci. Instrum.). The development of this high-sensitivity instrumentation led to the discovery of magnetosensitive photochemistry of flavin adenine dinucleotide (FAD) at physiological pH (see J. Phys. Chem. Lett.) and the first reported low field effect (LFE) on FAD photochemistry, the mechanism by which migratory birds are proposed to sense the geomagnetic field to navigate across the world (see Angew. Chem. Int. Ed.). His efforts were awarded with a Best Poster Prize at the 2017 Spin Chemistry Meeting, The First National High School Memorial Award (一高記念賞) and graduated as valedictorian (卒業生代表).

    During his JSPS Postdoctoral Fellowship (2018-2019, nominated by The Royal Society) at Saitama University and his independent JST PRESTO (さきがけ) Research Fellowship (2019-2023), he developed the most sensitive magnetic field effect-based technique to date, named magneto-fluorescence fluctuation microspectroscopy (MFFMS), a fluorescence-based microspectroscope that enables quantum spin effects on biomolecules to be observed at single-photon levels. This work was awarded a Best Presentation Award and Best Poster Prizes (by students) at domestic and international conferences (here and here) and was recently published in a Nature Photonics and featured in Nature Photonics News & Views.

    During this time, he started to co-develop the open-source object-oriented spin dynamics software RadicalPy, which was recently published in the Journal of Chemical Theory and Computation. This software is designed to provide a versatile framework for students and researchers to perform correct and complex radical pair spin dynamics simulations with relative ease.

    He then moved to the University of Oxford in early 2023 as a Research Associate to investigate quantum phenomena in cryptochrome proteins for avian magnetoreception and singlet fission materials. He was shortlisted for a Junior Research Fellowship (JRF) at New College, University of Oxford before deciding to move to S. Korea, where since December 2024, he has been running his own group that focuses on understanding the influence of quantum effects on biological function and their medical applications in the Institute of Quantum Biophysics (IQB) at Sungkyunkwan University (SKKU).

    He is currently organising and running the Spin Chemistry Graduate Seminar Series (SCGSS), whose aim is to give graduate students the opportunity to present their research, in English, in an online conference format. His contributions to the field of spin chemistry were recognised and awarded with the honour of becoming the youngest member of the prestigious International Spin Chemistry Committee and appointed as a Visiting Academic at the University of Oxford in 2024. He is also a Guest Editor for PLOS Computational Biology and a Member of the Royal Society of Chemistry and Royal Microscopical Society.


    Professional Experience

    Research Professor (Principal Investigator) Sungkyunkwan University, S. Korea - 2024/12-Present
    Visiting Academic University of Oxford, UK - 2024/12-Present
    Research Associate in Laser Photochemistry and Spectroscopy University of Oxford, UK - 2023/04-2024/11
    Advisors: Prof. Peter J. Hore, Prof. Christiane R. Timmel, Prof. Stuart R. Mackenzie
    Independent PRESTO Researcher / Special Project Researcher Japan Science and Technology Agency / Saitama University, Japan - 2019/10-2023/03
    JSPS Postdoctoral Fellowship for Research in Japan Saitama University, Japan - 2018/10-2019/09
    Advisor: Prof. Kiminori Maeda
    Nominated by The Royal Society

    Education

    Ph. D. in Environmental Sciences The University of Tokyo, Japan - 2014-2018
    Thesis: Spatially resolved microspectroscopy of flavin-based magnetosensitive (フラビンに基づく磁気感受性光化学の空間分解顕微分光)
    Graduated as Valedictorian (卒業生代表)
    The First National High School Memorial Award (一高記念賞)
    Supervisor: Prof. Jonathan R. Woodward
    M. Chem. in Chemistry (with a Year Abroad) University of Leicester, UK (Year abroad: University of Stuttgart, Germany) - 2010-2014
    Royal Society of Chemistry Accredited Degree
    Fourth year thesis: The determination of total atmospheric hydroxyl radical reactivity with the development of the comparative reactivity method - First Class
    Supervisor: Prof. Paul S. Monks
    Third year thesis: Liquid crystalline aryl guanidinium ions: effects of bending on the mesomorphic properties - First Class
    Supervisor: Prof. Dr. Sabine Laschat

    Awards

    Best Presentation Award The 3rd Annual Meeting of the Quantum Life Science Society Conference (第3回量子生命科学会) - 2021/09
    EFEPR Scholarship International EPR (ESR) Society - 2019/11
    The First National High School Memorial Award (一高記念賞) Best academic performance and dissertation in the year - 2019/03
    Valedictorian (卒業生代表) The University of Tokyo - 2018/09
    Best Poster Prize Spin Chemistry Meeting 2017 (Taylor & Francis) - 2017/09
    2017 International Conference Travel Grant The University of Tokyo - 2017/05
    Member of the Royal Society of Chemistry - 2016
    MEXT Scholarship for Ph. D. - 2014/08
    ERASMUS Scholarship for M. Chem. - 2012/07

    Teaching Experience

    Student Supervisor Saitama University, University of Oxford, Sungkyunkwan University - 2019-Present
    Guest Lecturer Saitama University, Japan - 2019-2023
    JSPS Science Dialogue Lecture Sendai Seiryo Secondary School, Japan - 2019
    Teaching Assistant The University of Tokyo, Japan - 2015-2017
    Komaba Writers Studio Teaching Assistant The University of Tokyo, Japan - 2015-2016
    Sports England Level 2 Coach British Ju-Jitsu Association Governing Body, UK - 2011-2014

    Funding

    JST ASPIRE for Rising Scientists (Co-PI) 60 million JPY - 2024/10-2027/09
    JST PRESTO International Reinforcement Support (PI) 3 million JPY - 2020/10-2021/03
    JST PRESTO (Quantum Bio) Creation of Life Science Basis By Using Quantum Technology (PI) 40 million JPY - 2019/10-2023/03
    Grant-in-Aid for JSPS Research Fellow (Co-PI) 4 million JPY - 2018/10-2019/09

    Professional Affiliations

    International Spin Chemistry Committee
    Royal Society of Chemistry (MRSC)
    Royal Institute of Navigation (MRIN)
    Royal Microscopical Society
    International EPR (ESR) Society
    Society of Electron Spin Science and Technology (SEST)
    European Microscopy Society
    International Society of Magnetic Resonance

    Group Members

    Graduate Students (in alphabetical order)

      ...

      Khanh Van Do (Đỗ Vân Khanh, with Minibrain Lab, SKKU)

      PhD Candidate

      Quantum spin effects on nanotube models for energy transfer in neurodegenerative diseases



      ...

      Damyan Frantzov (with Timmel Group, University of Oxford)

      DPhil Student

      RadicalPy software development



      ...

      Gaeun Lee (이가은, with MTBS Lab, SKKU)

      PhD Student

      TBD


      ...

      Beniel Jones Rajasekaran (பெனியேல் ஜோன்ஸ் இராஜசேகரன், with LAMP4PPM Lab, SKKU)

      PhD Candidate

      Development of room-temperature qubits and qubit enhanced spintronics sensors



      ...

      Chihe Ko (고지해, with BNP Lab, SKKU)

      MS/PhD Student

      TBD



      ...

      Dongjae Kim (김동재, with BNP Lab, SKKU)

      MS/PhD Student

      TBD



      ...

      Hyeong Jin Ahn (안형진, with MTBS Lab, SKKU)

      MS/PhD Student

      TBD



      ...

      Minjoon An (안민준, with Minibrain Lab, SKKU)

      MS/PhD Student

      Quantum coherence in microtubules for reconstructing neuronal circuits



      ...

      Sharon Jeeho Ham (함지호, with MTBS Lab, SKKU)

      MS/PhD Student

      TBD



      ...

      Minwoo Kim (김민우, with Minibrain Lab, SKKU)

      MS/PhD Student

      Quantum coherence in solitons for ATP restoration in neurodegenerative diseases



      ...

      Tae Hoon Kim (김태훈, with MTBS Lab, SKKU)

      MS/PhD Student

      TBD



      ...

      Kiyeon Park (박기연, with MTBS Lab, SKKU)

      MS/PhD Student

      TBD

    Alumni

    Master's

    • Mizuki Kohmura (香村泉希, with Maeda Lab, Saitama University)
    • Ayumi Fukai (深井歩実, with Maeda Lab, Saitama University)
    • Chiho Jimbo (神保知歩, with Maeda Lab, Saitama University)
    • Minori Fujita (藤田みのり, with Maeda Lab, Saitama University)

    Undergraduate

    • Hiroya Matsuda (松田大弥, with Maeda Lab, Saitama University)
    • Wataru Fushimoto (伏本航, with Maeda Lab, Saitama University)
    • Ai Hatayama (畑山愛, with Maeda Lab, Saitama University)
    ... ...

    QUBE Lab

    Tackling key questions in quantum biophysics

    Institute of Quantum Biophysics, Department of Biophysics, Sungkyunkwan University

    lewis.antill@g.skku.edu

    Keywords: Spin Chemistry, Quantum Biophysics, Quantum Biology, Quantum Sensing, Microscopy, Spectroscopy, Photochemistry, Spin Dynamics Simulation, Molecular Dynamics Simulation, Computer Programming, Software Design, Protein Synthesis